Alzheimer’’s and Drugs: Exploring Treatment Options
July 27, 2008 · Print This Article
Alzheimer’s disease is a devastating brain disease that scientists find difficult not only to understand but also to treat. By studying the effects of the disease process in Alzheimer’s patients’ brains—a combination of plaques between neurons and tangles within neurons—scientists are able to experiment with a variety of drugs to slow the damage to the brain and to improve the quality and duration of patients’ lives. The effectiveness of drugs for a person with Alzheimer’s disease, however, is debatable, and a cure remains as elusive as the cause.
The most widely used and the only FDA-approved group of drugs for a person with Alzheimer’s disease involve a chemical compound called acetylcholine, which is important for the functioning of neurons in the brain. Persons with Alzheimer’s disease are found to have low levels of acetylcholine, so drugs such as Aricept, Exelon, and Reminyl attempt to inhibit the production of the enzyme Acetylcholinesterase, which eats away at healthy acetylcholine. Debate rages about just how effective the drugs are at improving cognitive functioning and slowing impairment because some patients with other serious health problems were not included in the studies on the drugs. Also, the drugs can have some unpleasant gastrointestinal side effects, such as nausea, diarrhea, and vomiting, so they have to be administered to patients in slowly increasing amounts over a period of time. Studies have found, though, that, in as many as twenty percent of Alzheimer’s patients taking acetylcholinesterase inhibitors, cognitive impairment is slowed by as much as a year, offering patients and their families precious time.
Several other types of drugs for a person with Alzheimer’s disease are being researched, but their effectiveness, by and large, has not been supported by studies. For example, vitamin E and nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, have been thought to combat the damaging effects of inflammation associated with plaque in the brains of Alzheimer’s patients. While not enough evidence exists for either one being an effective treatment for a person with Alzheimer’s disease, NSAIDs have been found to offer some protection. Another potential preventative drug is estrogen, a hormone often taken by postmenopausal women, which has been found to keep the brain healthier and younger by increasing cerebral metabolism. While studies show that estrogen can decrease the chances of developing Alzheimer’s disease, the hormone, when combined with the hormone progestin, has been linked to a greater incidence of cardiovascular problems, such as strokes; therefore, estrogen is not recommended as a treatment for Alzheimer’s. Ginkgo biloba, a popular plant extract associated with improving brain function, has also been found to have dangerous side effects, so, despite studies which show it as a mildly effective treatment for Alzheimer’s, it is not recommended for patients.
Finally, selegiline, which is a type of antidepressant, has been studied as a potential treatment for some of the effects of Alzheimer’s, such as certain behaviors and moods, but research is not supportive enough for scientists to endorse it. In the end, while researchers have found some drugs to be more effective that other drugs for a person with Alzheimer’s disease, patients and their families must make their own decisions regarding treatment options.